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ABSTRACT: Background
Classification of COPD is usually based on the severity of airflow, which may not sensitively differentiate subpopulations. Using a multiscale imaging-based cluster analysis (MICA), we aim to identify subpopulations for current smokers with COPD.Methods
Among the SPIROMICS subjects, we analyzed computed tomography images at total lung capacity (TLC) and residual volume (RV) of 284 current smokers. Functional variables were derived from registration of TLC and RV images, e.g. functional small airways disease (fSAD%). Structural variables were assessed at TLC images, e.g. emphysema and airway wall thickness and diameter. We employed an unsupervised method for clustering.Results
Four clusters were identified. Cluster 1 had relatively normal airway structures; Cluster 2 had an increase of fSAD% and wall thickness; Cluster 3 exhibited a further increase of fSAD% but a decrease of wall thickness and airway diameter; Cluster 4 had a significant increase of fSAD% and emphysema. Clinically, Cluster 1 showed normal FEV1/FVC and low exacerbations. Cluster 4 showed relatively low FEV1/FVC and high exacerbations. While Cluster 2 and Cluster 3 showed similar exacerbations, Cluster 2 had the highest BMI among all clusters.Conclusions
Association of imaging-based clusters with existing clinical metrics suggests the sensitivity of MICA in differentiating subpopulations.
SUBMITTER: Haghighi B
PROVIDER: S-EPMC6145340 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Haghighi Babak B Choi Sanghun S Choi Jiwoong J Hoffman Eric A EA Comellas Alejandro P AP Newell John D JD Graham Barr R R Bleecker Eugene E Cooper Christopher B CB Couper David D Han Mei Lan ML Hansel Nadia N NN Kanner Richard E RE Kazerooni Ella A EA Kleerup Eric A C EAC Martinez Fernando J FJ O'Neal Wanda W Rennard Stephen I SI Woodruff Prescott G PG Lin Ching-Long CL
Respiratory research 20180918 1
<h4>Background</h4>Classification of COPD is usually based on the severity of airflow, which may not sensitively differentiate subpopulations. Using a multiscale imaging-based cluster analysis (MICA), we aim to identify subpopulations for current smokers with COPD.<h4>Methods</h4>Among the SPIROMICS subjects, we analyzed computed tomography images at total lung capacity (TLC) and residual volume (RV) of 284 current smokers. Functional variables were derived from registration of TLC and RV images ...[more]