Subgingival microbiome of rheumatoid arthritis patients in relation to their disease status and periodontal health.

ABSTRACT:

Objective

Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that share common risk factors. However, the bidirectional relationship between RA and periodontal disease is not fully understood. This study was undertaken to describe the bacterial component of the subgingival microbiome in RA patients and to relate this to RA disease activity and periodontal status.

Methods

Patients with chronic established RA (N = 78) were periodontally examined and their subgingival plaque samples were collected; their clinical and laboratory data on RA status and medication were obtained from medical records. Bacterial DNA was quantified by universal 16S rDNA qPCR, and Porphyromonas gingivalis by species-specific qPCR. For microbiome assessment, 16S rDNA amplicon s

SUBMITTER: Beyer K 

PROVIDER: S-EPMC6145512 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature