Ontology highlight
ABSTRACT:
SUBMITTER: Mushiroda T
PROVIDER: S-EPMC6145764 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Mushiroda Taisei T Takahashi Yukitoshi Y Onuma Teiichi T Yamamoto Yoshiaki Y Kamei Tetsumasa T Hoshida Tohru T Takeuchi Katsuya K Otsuka Kotaro K Okazaki Mitsutoshi M Watanabe Masako M Kanemoto Kosuke K Oshima Tomohiro T Watanabe Atsushi A Minami Shiro S Saito Kayoko K Tanii Hisashi H Shimo Yasushi Y Hara Minoru M Saitoh Shinji S Kinoshita Toshihiko T Kato Masaki M Yamada Naoto N Akamatsu Naoki N Fukuchi Toshihiko T Ishida Shigenobu S Yasumoto Shingo S Takahashi Atsushi A Ozeki Takeshi T Furuta Takahisa T Saito Yoshiro Y Izumida Nobuyuki N Kano Yoko Y Shiohara Tetsuo T Kubo Michiaki M
JAMA neurology 20180701 7
<h4>Importance</h4>Carbamazepine, a commonly used antiepileptic drug, is one of the most common causes of cutaneous adverse drug reactions (cADRs) worldwide. The allele HLA-A*31:01 is reportedly associated with carbamazepine-induced cADRs in Japanese and European populations; however, the clinical utility of HLA-A*31:01 has not been evaluated.<h4>Objective</h4>To assess the use of HLA-A*31:01 genetic screening to identify Japanese individuals at risk of carbamazepine-induced cADRs.<h4>Design, se ...[more]