Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis.

ABSTRACT: Change in body composition with skeletal muscle wasting, a major component of pulmonary cachexia, is associated with mortality in chronic obstructive pulmonary disease and cancer. However, its relevance in interstitial lung diseases (ILDs) remains unclear. We hypothesized changes in body composition would be associated with mortality in ILDs. We measured the cross-sectional-area (ESM_CSA) and muscle attenuation (ESM_MA) of erector-spinae muscles, as determined by CT-imaging, in patients with idiopathic pulmonary fibrosis (IPF; n = 131) and idiopathic pleuroparenchymal fibroelastosis (iPPFE; n = 43) and controls. Subsequently, implications with prognosis were evaluated. The ESM_CSA of ILD patients, but not ESM_MA, was significantly smaller than that i

SUBMITTER: Suzuki Y 

PROVIDER: S-EPMC6145941 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature