Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention.
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ABSTRACT:
SUBMITTER: Basnet R
PROVIDER: S-EPMC6146383 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention.
Basnet Rajesh R Gong Grace Qun GQ Li Chenyao C Wang Ming-Wei MW
Acta pharmaceutica Sinica. B 20180705 5
The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, a ...[more]
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