Ontology highlight
ABSTRACT:
SUBMITTER: Kaypee S
PROVIDER: S-EPMC6147029 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
iScience 20180607
The transcriptional co-activator p300 is essential for p53 transactivation, although its precise role remains unclear. We report that p53 activates the acetyltransferase activity of p300 through the enhancement of p300 autoacetylation. Autoacetylated p300 accumulates near the transcription start sites accompanied by a similar enrichment of activating histone marks near those sites. Abrogation of p53-p300 interaction by a site-directed peptide inhibitor abolished p300-mediated histone acetylation ...[more]