Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki JI
PROVIDER: S-EPMC6148218 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Suzuki Jun-Ichiro JI Kodera Yukihiro Y Miki Satomi S Ushijima Mitsuyasu M Takashima Miyuki M Matsutomo Toshiaki T Morihara Naoaki N
Scientific reports 20180920 1
The degradation of target proteins by small molecules utilizing the cellular proteolytic system is featured as a treatment strategy of several diseases. We found that S-1-propenylcysteine (S1PC) among several cysteine derivatives in aged garlic extract inhibited TLR-mediated IL-6 production by inducing the degradation of adaptor protein MyD88. We showed that S1PC directly denatured MyD88 and induced the formation of protein aggregates. Consequently, MyD88 was degraded by aggresome-autophagy path ...[more]