Ontology highlight
ABSTRACT:
SUBMITTER: Sobczak AIS
PROVIDER: S-EPMC6148461 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Sobczak Amélie I S AIS Pitt Samantha J SJ Stewart Alan J AJ
Metallomics : integrated biometal science 20180901 9
Heparan sulfate (HS), dermatan sulfate (DS) and heparin are glycosaminoglycans (GAGs) that serve as key natural and pharmacological anticoagulants. During normal clotting such agents require to be inactivated or neutralised. Several proteins have been reported to facilitate their neutralisation, which reside in platelet α-granules and are released following platelet activation. These include histidine-rich-glycoprotein (HRG), fibrinogen and high-molecular-weight kininogen (HMWK). Zinc ions (Zn2+ ...[more]