Ontology highlight
ABSTRACT:
SUBMITTER: Stringer JM
PROVIDER: S-EPMC6149058 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
BMC biology 20180920 1
<h4>Background</h4>Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that regulate epigenetic information in the germline and its transmission to offspring are poorly understood.<h4>Results</h4>Here we provide evidence that Polycomb Repressive Complex 2 (PRC2) regulates paternal inheritance. Reduced PRC2 function in mice resulted in male sub-fert ...[more]