Ontology highlight
ABSTRACT:
SUBMITTER: Khan MM
PROVIDER: S-EPMC6149218 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Khan Mohd M MM Koppenol-Raab Marijke M Kuriakose Minna M Manes Nathan P NP Goodlett David R DR Nita-Lazar Aleksandra A
Journal of proteomics 20180320
The pattern recognition receptors (PRRs) facilitate an organism's first line of defense against interlopers and shape the overall innate immune response through sensing and sampling pathogen-associated molecular patterns (PAMPs). The Toll-like receptor (TLR) family is the prototypic PRR family. Upon recognition of PAMPs, TLRs promote MyD88 dependent and independent responses. Understanding how different PAMPs are recognized by their specific TLRs and how pathogen recognition initiates immune act ...[more]