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Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase.

ABSTRACT: Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents.

SUBMITTER: Khunnawutmanotham N

PROVIDER: S-EPMC6149348 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase.

Khunnawutmanotham Nisachon N Chimnoi Nitirat N Saparpakorn Patchareenart P Pungpo Pornpan P Louisirirotchanakul Suda S Hannongbua Supa S Techasakul Supanna S

Molecules (Basel, Switzerland) 20070220 2

Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents. ...[more]

PMID: 17846572

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