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Hippeastrum reticulatum (Amaryllidaceae): Alkaloid Profiling, Biological Activities and Molecular Docking.

ABSTRACT: The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6?-hydroxymaritidine and 6?-hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6?-hydroxymaritidine, 6?-hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6?-hydroxymaritidine and 6?-hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, ?-? stacking and hydrophobic interactions.

SUBMITTER: Tallini LR 

PROVIDER: S-EPMC6149799 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Hippeastrum reticulatum (Amaryllidaceae): Alkaloid Profiling, Biological Activities and Molecular Docking.

Tallini Luciana R LR   Osorio Edison H EH   Santos Vanessa Dias Dos VDD   Borges Warley de Souza WS   Kaiser Marcel M   Viladomat Francesc F   Zuanazzi José Angelo S JAS   Bastida Jaume J  

Molecules (Basel, Switzerland) 20171209 12

The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of <i>Hippeastrum reticulatum</i> (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). Twelve alkaloi  ...[more]

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