Dataset Information

Association between bronchopulmonary dysplasia and cerebral palsy in children: a meta-analysis.

ABSTRACT: OBJECTIVE:To investigate the association between bronchopulmonary dysplasia (BPD) and the risk of cerebral palsy (CP) in children. DATA SOURCES:We used EMBASE, PubMed and Web of Science to conduct a meta-analysis of studies published before 1 September 2017, written in English whose titles or abstracts discussed an association between BPD and CP. STUDY SELECTION:Observational studies, for example, case-control and cohort studies were included. DATA EXTRACTION AND SYNTHESIS:All review stages were conducted by two reviewers independently. Data synthesis was undertaken via meta-analysis of available evidence. MAIN OUTCOMES AND MEASURES:The prevalence of developing CP was measured after exposure to BPD. RESULTS:Among 1234 initially identified studies, we selected those that addressed an association between BPD and CP according to our preselected inclusion criteria. Our meta-analysis included 11 studies. According to a random effect model, BPD was significantly associated with CP (ORs 2.10; 95%?CI 1.57 to 2.82) in preterm infants. Factors explaining differences in the study results included study design, the definition of BPD, the time of diagnosis of CP and whether the studies adjusted for potential confounders. CONCLUSION:This study suggests that BPD is a risk factor for CP. Further studies are required to confirm these results and to detect the influence of variables across studies.

SUBMITTER: Gou X

PROVIDER: S-EPMC6150141 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Association between bronchopulmonary dysplasia and cerebral palsy in children: a meta-analysis.

Gou Xiaoyun X Yang Lei L Pan Lingli L Xiao Dongqiong D

BMJ open 20180919 9

<h4>Objective</h4>To investigate the association between bronchopulmonary dysplasia (BPD) and the risk of cerebral palsy (CP) in children.<h4>Data sources</h4>We used EMBASE, PubMed and Web of Science to conduct a meta-analysis of studies published before 1 September 2017, written in English whose titles or abstracts discussed an association between BPD and CP.<h4>Study selection</h4>Observational studies, for example, case-control and cohort studies were included.<h4>Data extraction and synthes ...[more]

PMID: 30232102

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Project description:BackgroundThere is a lack of consensus on the management of thrombocytopenia in preterm infants, and the threshold for prophylactic platelet transfusion varies widely among clinicians and institutions. Reports in animal models suggested that platelets may play a relevant role in lung alveolarization and regeneration. Bronchopulmonary dysplasia (BPD) is a severe respiratory condition with a multifactorial origin that affects infants born at the early stages of lung development. Recent randomized controlled trials on the platelets count threshold for prophylactic transfusions in preterm infants with thrombocytopenia suggest that a higher exposition to platelet transfusion may increase the risk of BPD. Here, we report a protocol for a systematic review, which aims to assist evidence-based clinical practice and clarify if the administration of platelet products may be associated with the incidence of BPD and/or death in preterm infants.MethodsMEDLINE, Embase, Cochrane databases, and sources of gray literature for conference abstracts and trial registrations will be searched with no time or language restrictions. Case-control studies, cohort studies, and nonrandomized or randomized trials that evaluated the risk for BPD and/or death in preterm infants exposed to platelet transfusion will be included. Data from studies that are sufficiently similar will be pooled as appropriate. Data extraction forms will be developed a priori. Observational studies and nonrandomized and randomized clinical trials will be analyzed separately. Odds ratio with 95% confidence interval (CI) for dichotomous outcomes and the mean difference (95% CI) for continuous outcomes will be combined. The expected heterogeneity will be accounted for using a random-effects model. Subgroup analysis will be performed based on a priori-determined covariate of interest. In case of sufficient homogeneity of interventions and outcomes evaluated, results from subgroups of studies will be pooled together in a meta-analysis.DiscussionThis systematic review will investigate the association of BPD/death with platelet components administration in preterm infants, and, consequently, it will provide reliable indications for the evidence-based management of premature patients with thrombocytopenia.

Dataset Information

Association between bronchopulmonary dysplasia and cerebral palsy in children: a meta-analysis.

Publications

Association between bronchopulmonary dysplasia and cerebral palsy in children: a meta-analysis.

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