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A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis.


ABSTRACT: A new nortriterpenoid, 19(R)-hydroxyl-wuweizidilactone H (1), and a sesquiterpene, (6R)-?-chamigrenic acid (2), together with one known nortriterpenoid, wuweizidilactone H (3), and three known hepatoprotective lignans, micrantherin A (4), gomisin M? (5) and schizandrin (6) were isolated from the fruit of Schisandra chinensis. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of 2 was confirmed for the first time. In vitro assays, compounds 4-6 (10 ?M) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by N-acetyl-p-aminophenol (APAP) in human liver carcinoma (HepG2) cells.

SUBMITTER: Li F 

PROVIDER: S-EPMC6150265 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis.

Li Fenghua F   Zhang Ting T   Sun Hua H   Gu Haifeng H   Wang Hongqing H   Su Xianming X   Li Changkang C   Li Baoming B   Chen Ruoyun R   Kang Jie J  

Molecules (Basel, Switzerland) 20171110 11


A new nortriterpenoid, 19(<i>R</i>)-hydroxyl-wuweizidilactone H (<b>1</b>), and a sesquiterpene, (6<i>R</i>)-<i>β</i>-chamigrenic acid (<b>2</b>), together with one known nortriterpenoid, wuweizidilactone H (<b>3</b>), and three known hepatoprotective lignans, micrantherin A (<b>4</b>), gomisin M₂ (<b>5</b>) and schizandrin (<b>6</b>) were isolated from the fruit of <i>Schisandra chinensis</i>. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the a  ...[more]

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