Non-Covalent Loading of Anti-Cancer Doxorubicin by Modularizable Peptide Self-Assemblies for a Nanoscale Drug Carrier.
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ABSTRACT:
SUBMITTER: Tomizaki KY
PROVIDER: S-EPMC6150382 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Non-Covalent Loading of Anti-Cancer Doxorubicin by Modularizable Peptide Self-Assemblies for a Nanoscale Drug Carrier.
Tomizaki Kin-Ya KY Kishioka Kohei K Kataoka Shunsuke S Miyatani Makoto M Ikeda Takuya T Komada Mami M Imai Takahito T Usui Kenji K
Molecules (Basel, Switzerland) 20171106 11
We prepared nanoscale, modularizable, self-assembled peptide nanoarchitectures with diameters less of than 20 nm by combining β-sheet-forming peptides tethering a cell-penetrating peptide or a nuclear localization signal sequence. We also found that doxorubicin (Dox), an anti-cancer drug, was non-covalently accommodated by the assemblies at a ratio of one Dox molecule per ten peptides. The Dox-loaded peptide assemblies facilitated cellular uptake and subsequent nuclear localization in HeLa cells ...[more]
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