Ontology highlight
ABSTRACT:
SUBMITTER: Ward J
PROVIDER: S-EPMC6150505 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ward Joey J Graham Nicholas N Strawbridge Rona J RJ Ferguson Amy A Jenkins Gregory G Chen Wenan W Hodgson Karen K Frye Mark M Weinshilboum Richard R Uher Rudolf R Lewis Cathryn M CM Biernacka Joanna J Smith Daniel J DJ
PloS one 20180921 9
There are currently no reliable approaches for correctly identifying which patients with major depressive disorder (MDD) will respond well to antidepressant therapy. However, recent genetic advances suggest that Polygenic Risk Scores (PRS) could allow MDD patients to be stratified for antidepressant response. We used PRS for MDD and PRS for neuroticism as putative predictors of antidepressant response within three treatment cohorts: The Genome-based Therapeutic Drugs for Depression (GENDEP) coho ...[more]