Dataset Information

Correlation between elastic energy stored in an eye and visual field progression in glaucoma.

ABSTRACT:

Purpose

To investigate whether the elastic energy stored in an eyeball at highest concavity (highest concavity energy; HCE), calculated with Corivs ST (CST, OCULUS), correlates with glaucomatous visual field (VF) progression.

Methods

108 eyes from 70 primary open angle-glaucoma patients were studied. The HCE was calculated using CST parameters. For each eye, the mean total deviation (mTD) of the 52 test points in the 24-2 Humphrey Field Analyzer test pattern was calculated and the mTD progression rate was determined from eight reliable VFs. Eyes were subdivided into: subgroups with low- or high-whole eye motion maximal length (WEM-d) and subgroups with short- or long-time taken to reach WEM-d (WEM-t), as measured with CST. The associations between mTD progression rate and HCE and other ocular/systemic parameters including age, Goldmann applanation tonometry based-intraocular pressure [GAT-IOP], and corneal hysteresis [CH] from the Ocular Response Analyzer (ORA®, Reichert) were investigated using the linear mixed model. The optimal model to describe mTD progression rate was selected from all possible combinations according to the second order bias corrected Akaike Information Criterion index.

Results

Optimal models to describe mTD progression rate included: CH in the model for all eyes, age and HCE in the model for the WEM-d low group, HCE in the model for the WEM-t short group, mean GAT-IOP in the model for the WEM-d high group, and age in the model for the WEM-t long-group.

Conclusions

HCE was associated with glaucomatous VF progression in eyes with minimal whole eye motion (low WEM-d and WEM-t subgroups).

SUBMITTER: Aoki S

PROVIDER: S-EPMC6150541 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Correlation between elastic energy stored in an eye and visual field progression in glaucoma.

Aoki Shuichiro S Murata Hiroshi H Nakakura Shunsuke S Nakao Yoshitaka Y Matsuura Masato M Kiuchi Yoshiaki Y Asaoka Ryo R

PloS one 20180921 9

<h4>Purpose</h4>To investigate whether the elastic energy stored in an eyeball at highest concavity (highest concavity energy; HCE), calculated with Corivs ST (CST, OCULUS), correlates with glaucomatous visual field (VF) progression.<h4>Methods</h4>108 eyes from 70 primary open angle-glaucoma patients were studied. The HCE was calculated using CST parameters. For each eye, the mean total deviation (mTD) of the 52 test points in the 24-2 Humphrey Field Analyzer test pattern was calculated and the ...[more]

PMID: 30240430

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Project description:PurposeTo evaluate the relationship between medication adherence and visual field progression in participants randomized to the medication arm of the Collaborative Initial Glaucoma Treatment Study (CIGTS).DesignThe CIGTS was a randomized, multicenter clinical trial comparing initial treatment with topical medications to trabeculectomy for 607 participants with newly diagnosed glaucoma.ParticipantsThree hundred seven participants randomized to the medication arm of the CIGTS.MethodsParticipants were followed up at 6-month intervals for up to 10 years. Self-reported medication adherence and visual fields were measured. Medication adherence was assessed by telephone from responses to the question, "Did you happen to miss any dose of your medication yesterday?" The impact of medication adherence on mean deviation (MD) over time was assessed with a linear mixed regression model adjusting for the effects of baseline MD and age, cataract extraction, interactions, and time (through year 8, excluding time after crossover to surgery). Medication adherence was modeled as a cumulative sum of the number of prior visits where a missed dose of medication was reported.Main outcome measureMean deviation over time.ResultsThree hundred seven subjects (306 with adherence data) were randomized to treatment with topical medications and followed up for an average of 7.3 years (standard deviation, 2.3 years). One hundred forty-two subjects (46%) reported never missing a dose of medication over all available follow-up, 112 patients (37%) reported missing medication at up to one third of visits, 31 patients (10%) reported missing medication at one third to two thirds of visits, and 21 patients (7%) reported missing medication at more than two thirds of visits. Worse medication adherence was associated with loss of MD over time (P = 0.005). For subjects who reported never missing a dose of medication, the average predicted MD loss over 8 years was 0.62 dB, consistent with age-related loss (95% confidence interval [CI], 0.17-1.06; P = 0.007); subjects who reported missing medication doses at one third of visits had a loss of 1.42 dB (95% CI, 0.86-1.98; P < 0.0001); and subjects who reported missing medication doses at two thirds of visits showed a loss of 2.23 dB (95% CI, 1.19-3.26; P < 0.0001).ConclusionsThis longitudinal assessment demonstrated a statistically and clinically significant association between medication nonadherence and glaucomatous vision loss.

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Dataset Information

Correlation between elastic energy stored in an eye and visual field progression in glaucoma.

Purpose

Methods

Results

Conclusions

Publications

Correlation between elastic energy stored in an eye and visual field progression in glaucoma.

Similar Datasets

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