Dataset Information

Etiology of optic atrophy: a prospective observational study from Saudi Arabia.

ABSTRACT:

Background

Optic atrophy (OA) represents permanent retinal ganglion cell loss warranting study to establish etiology.

Objectives

To describe neurogenic causes of OA.

Design

Prospective, observational.

Setting

Tertiary care center, Riyadh, Saudi Arabia.

Patients and methods

We included consecutive patients of all ages with OA caused by lesions affecting the visual pathways who were referred over a 9-month period (November 2013 to July 2014). Diagnosis was based on visual acuity, ophthalmoscopic features and ancillary tests. Patient demographics, results of a clinical examination, test data and etiology were recorded. For each cause of OA, both gender and age group were analyzed as potential risk factors using simple univariate logistic regression. OA associated with glaucoma and retinal diseases was excluded.

Main outcome measure

Description of causes of OA.

Results

Two hundred and four patients and 353 eyes met inclusion criteria. The median age was 27 years (range 3 months-77 years; interquartile range, 27 years) among 111(54.4%) females and 93(45.6%) males, with no statistically significant difference in age of presentation between the genders. The majority of lesions were bilateral (n=151, 74%). Tumors were the most common cause, accounting for 127 (62.2%) cases. These occurred mostly in adults (72.4%) compared to the pediatric group (OR=3.3, 95% CI: 1.79-6.03; P < .001). Hereditary neoplasia (OR=5.55; 95% CI: 1.67-18.42; P=.005) and metabolic diseases (OR=17.57; 95% CI: 2.15-143.62; P=.007) were more common causes in the pediatric group. There were no significant associations between gender or visual acuity and etiology of OA. In developed nations, OA is frequently the result of ischemia and neuritis. We found many other causes, especially orbital and intracranial tumors.

Conclusions

The frequency of tumors as the cause of OA may represent a higher incidence of aggressive tumors coupled with poor recognition/acknowledgement of symptoms and limited access, resulting in late presentations.

Limitations

These findings may reflect bias from selective referrals to a tertiary center and may not represent all of Saudi Arabia.

SUBMITTER: Mbekeani JN

PROVIDER: S-EPMC6150579 | biostudies-literature | 2017 May-Jun

REPOSITORIES: biostudies-literature

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Publications

Etiology of optic atrophy: a prospective observational study from Saudi Arabia.

Mbekeani Joyce N JN Fattah Maaly Abdel MA Poulsen David M DM Hazzaa Selwa Al SA Dababo M Anas MA Eldali Abdelmoneim A Ahmed Manzoor M

Annals of Saudi medicine 20170501 3

<h4>Background</h4>Optic atrophy (OA) represents permanent retinal ganglion cell loss warranting study to establish etiology.<h4>Objectives</h4>To describe neurogenic causes of OA.<h4>Design</h4>Prospective, observational.<h4>Setting</h4>Tertiary care center, Riyadh, Saudi Arabia.<h4>Patients and methods</h4>We included consecutive patients of all ages with OA caused by lesions affecting the visual pathways who were referred over a 9-month period (November 2013 to July 2014). Diagnosis was based ...[more]

PMID: 28578363

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Project description:Background: Labor pain is one of the most excruciatingly painful sensations a woman can have. A woman's attitude toward childbirth might be influenced by her lack of understanding of the birth process and the pain she experiences throughout labor and delivery. The control of pain is an important aspect of appropriate obstetrical care. Our study aims to measure the level of awareness, preconception, and fear of epidural analgesia (EDA) among childbearing women. Methods: An observational cross-sectional, hospital-based study was conducted using a self-administered questionnaire. The study included all pregnant women who were attending an obstetrical clinic for routine antenatal follow-up at King Khalid university hospital in Riyadh, Saudi Arabia, during the month of August 2022. They were asked about five main parts that tapped their awareness, preconception, and fear of EDA. Data were analyzed by SPSS version 26 using descriptive methods, including mean, frequency, and percentage, and also Pearson's correlation coefficient for regression analysis to find the correlation between socio-demographics and awareness and between awareness and fear. Results: Participants in our study included 202 childbearing women. Most women, about 113 (55.9%), participating in the study were aged between 25 and 34 years old. The majority of the participants of this study were Saudi, about 196 (97.0%). In terms of education, 120 (59.4%) of the participants graduated from university. One hundred and forty two (70.3%) of the participants had a monthly income of less than 10000. When it comes to parity, the majority of participants, about 102 (50.5%), have had more than two pregnancies. The average percentage of awareness among the participants showed 45.9%, with an insignificant very moderate correlation between parity and awareness (r = -0.088, P = 0.107); women's knowledge, income, and age were also insignificantly related to awareness. Also, the result showed a moderate level of fear with an average percentage of 44.6% among the participants, with a moderate correlation between awareness and fear with a value of (r = 0.184, P = 0.004). Conclusion: This study results demonstrate a good level of desirability toward using EDA for labor pain, yet there is a limited level of preconceptions and a low level of awareness and knowledge about EDA. In addition, the results showed that the average percentage of fear is 44.6%. Therefore, we suggest that more awareness, knowledge, and guidance about EDA should be provided to pregnant women through antenatal clinics. Furthermore, educational campaigns should be made to dispel misconceptions and fears about EDA.

Dataset Information

Etiology of optic atrophy: a prospective observational study from Saudi Arabia.

Background

Objectives

Design

Setting

Patients and methods

Main outcome measure

Results

Conclusions

Limitations

Publications

Etiology of optic atrophy: a prospective observational study from Saudi Arabia.

Similar Datasets

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