Ontology highlight
ABSTRACT:
SUBMITTER: Nemmara VV
PROVIDER: S-EPMC6150842 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nemmara Venkatesh V VV Tilvawala Ronak R Salinger Ari J AJ Miller Lacey L Nguyen Son Hong SH Weerapana Eranthie E Thompson Paul R PR
ACS chemical biology 20180808 9
Nicotinamide- N-methyltransferase (NNMT) catalyzes the irreversible methylation of nicotinamide (NAM) to form N-methyl nicotinamide using S-adenosyl methionine as a methyl donor. NNMT is implicated in several chronic disease conditions, including cancers, kidney disease, cardiovascular disease, and Parkinson's disease. Although phosphorylation of NNMT in gastric tumors is reported, the functional effects of this post-translational modification has not been investigated. We previously reported th ...[more]