Unknown

Dataset Information

0

Worth a local treatment? - Analysis of modern radiotherapy concepts for oligometastatic prostate cancer.


ABSTRACT: BACKGROUND:Prostate cancer (PCA) is the most-prevalent non-skin cancer in men worldwide. Nevertheless, the treatment of oligometastatic, especially lymph-node (ln) recurrent, PCA remains elusive. The aim of our study was to provide insights in radiotherapy (RT)-treatment of recurrent PCA exhibiting ln- or osseous (oss)-oligometastases. METHODS:Between April 2012 and April 2017, 27 oligometastatic PCA patients (19 ln and 8 single oss) were treated with RT at our institution. RESULTS:The metastasis-free survival (MFS) was 24.8 m (22.0-36.0 m) and 25.4 m (23.9-28.1 m) for the ln- and oss-subgroup resulting in 1-year MFS of 75.4 and 100% and 2-year MFS of 58.7 and 83.3% for ln- and oss-metastatic patients, respectively. Of notice, none of the recurrences for ln-patients was in the RT-field, constituting a local control of 100%. Within the ln-group, pre-RT median-PSA was 2.6 ng/ml, median post-RT PSA was 0.3 ng/ml, which was significant (p?=?0.003). Median biochemical-free survival (bfS) was 12.2 m. PCA that was initially confined to the prostate had a better bfS (p?

SUBMITTER: Oertel M 

PROVIDER: S-EPMC6150968 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Worth a local treatment? - Analysis of modern radiotherapy concepts for oligometastatic prostate cancer.

Oertel M M   Scobioala S S   Kroeger K K   Baehr A A   Stegger L L   Haverkamp U U   Schäfers M M   Eich H-T HT  

Radiation oncology (London, England) 20180921 1


<h4>Background</h4>Prostate cancer (PCA) is the most-prevalent non-skin cancer in men worldwide. Nevertheless, the treatment of oligometastatic, especially lymph-node (ln) recurrent, PCA remains elusive. The aim of our study was to provide insights in radiotherapy (RT)-treatment of recurrent PCA exhibiting ln- or osseous (oss)-oligometastases.<h4>Methods</h4>Between April 2012 and April 2017, 27 oligometastatic PCA patients (19 ln and 8 single oss) were treated with RT at our institution.<h4>Res  ...[more]

Similar Datasets

| S-EPMC8738893 | biostudies-literature
| S-EPMC8738892 | biostudies-literature
| S-EPMC8799158 | biostudies-literature
| S-EPMC8189311 | biostudies-literature
| S-EPMC4066290 | biostudies-literature
| S-EPMC6790793 | biostudies-literature
| S-EPMC5083765 | biostudies-other
| S-EPMC5718249 | biostudies-literature
| S-EPMC6868044 | biostudies-literature
| S-EPMC7101059 | biostudies-literature