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Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection.

ABSTRACT: We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.

SUBMITTER: Shan Z 

PROVIDER: S-EPMC6151074 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection.

Shan Zhilei Z   Clish Clary B CB   Hua Simin S   Scott Justin M JM   Hanna David B DB   Burk Robert D RD   Haberlen Sabina A SA   Shah Sanjiv J SJ   Margolick Joseph B JB   Sears Cynthia L CL   Post Wendy S WS   Landay Alan L AL   Lazar Jason M JM   Hodis Howard N HN   Anastos Kathryn K   Kaplan Robert C RC   Qi Qibin Q  

The Journal of infectious diseases 20180901 9

We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with  ...[more]

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