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Inflammatory signaling and metabolic regulation by nitro-fatty acids.

ABSTRACT: The addition of nitrogen dioxide (NO2) to the double bond of unsaturated fatty acids yields an array of electrophilic nitro-fatty acids (NO2-FA) with unique biochemical and signaling properties. During the last decade, NO2-FA have been shown to exert a protective role in various inflammatory and metabolic disorders. NO2-FA exert their biological effects primarily by regulating two central physiological adaptive responses: the canonical inflammatory signaling and metabolic pathways. In this mini-review, we summarize current knowledge on the regulatory role of NO2-FA in the inflammatory and metabolic response via regulation of nuclear factor kappa B (NF-?B) and peroxisome proliferator-activated receptor ? (PPAR?), master regulators of inflammation and metabolism. Moreover, the engagement of novel signaling and metabolic pathways influenced by NO2-FA, beyond NF-?B and PPAR signaling, is discussed herein.

SUBMITTER: Rom O

PROVIDER: S-EPMC6151155 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Inflammatory signaling and metabolic regulation by nitro-fatty acids.

Rom Oren O Khoo Nicholas K H NKH Chen Y Eugene YE Villacorta Luis L

Nitric oxide : biology and chemistry 20180322

The addition of nitrogen dioxide (NO2) to the double bond of unsaturated fatty acids yields an array of electrophilic nitro-fatty acids (NO2-FA) with unique biochemical and signaling properties. During the last decade, NO2-FA have been shown to exert a protective role in various inflammatory and metabolic disorders. NO2-FA exert their biological effects primarily by regulating two central physiological adaptive responses: the canonical inflammatory sig ...[more]

PMID: 29578057

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