Inflammatory signaling and metabolic regulation by nitro-fatty acids.
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ABSTRACT:
SUBMITTER: Rom O
PROVIDER: S-EPMC6151155 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Inflammatory signaling and metabolic regulation by nitro-fatty acids.
Rom Oren O Khoo Nicholas K H NKH Chen Y Eugene YE Villacorta Luis L
Nitric oxide : biology and chemistry 20180322
The addition of nitrogen dioxide (NO<sub>2</sub>) to the double bond of unsaturated fatty acids yields an array of electrophilic nitro-fatty acids (NO<sub>2</sub>-FA) with unique biochemical and signaling properties. During the last decade, NO<sub>2</sub>-FA have been shown to exert a protective role in various inflammatory and metabolic disorders. NO<sub>2</sub>-FA exert their biological effects primarily by regulating two central physiological adaptive responses: the canonical inflammatory sig ...[more]
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