Ontology highlight
ABSTRACT:
SUBMITTER: Syed SA
PROVIDER: S-EPMC6151182 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Syed Shariful A SA Beurel Eléonore E Loewenstein David A DA Lowell Jeffrey A JA Craighead W Edward WE Dunlop Boadie W BW Mayberg Helen S HS Dhabhar Firdaus F Dietrich W Dalton WD Keane Robert W RW de Rivero Vaccari Juan Pablo JP Nemeroff Charles B CB
Neuron 20180823 5
Inflammation has been involved in the pathophysiology and treatment response of major depressive disorder (MDD). Plasma cytokine profiles of 171 treatment-naive MDD patients (none of the MDD patients received an adequate trial of antidepressants or evidence-based psychotherapy) and 64 healthy controls (HCs) were obtained. MDD patients exhibited elevated concentrations of 18 anti- and proinflammatory markers and decreased concentrations of 6 cytokines. Increased inflammasome protein expression wa ...[more]