Ontology highlight
ABSTRACT:
SUBMITTER: Oniga SD
PROVIDER: S-EPMC6151395 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Oniga Smaranda Dafina SD Pacureanu Liliana L Stoica Cristina Ioana CI Palage Mariana Doina MD Crăciun Alexandra A Rusu Laurentiu Răzvan LR Crisan Elena-Luminita EL Araniciu Cătălin C
Molecules (Basel, Switzerland) 20170909 9
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that exhibit frequent and sometimes severe adverse effects, including gastrointestinal ulcerations and cardiovascular disorders. In an effort to obtain safer NSAIDs, we assessed the direct cyclooxygenase (COX) inhibition activity and we investigated the potential COX binding mode of some previously reported 2-(trimethoxyphenyl)-thiazoles. The in vitro COX inhibition assays were performed against ovine COX-1 and h ...[more]