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Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity.

ABSTRACT: Haematoxylum campechianum is a medicinal plant employed as an astringent to purify the blood and to treat stomach problems such as diarrhea and dysentery. A bio-guided chemical fractionation of the methanolic extract obtained from this plant allowed for the isolation of five compounds: two chalcones known as sappanchalcone (1); 3-deoxysappanchalcone (2); three homoisoflavonoids known as hematoxylol A (3); 4-O-methylhematoxylol (4); and, hematoxin (5). The spasmolytic activity was determined in an in vitro model (electrically induced contractions of guinea pig ileum), and allowed to demonstrate that the methanolic extract (EC50 = 62.11 ± 3.23) fractions HcF7 (EC50 = 61.75 ± 3.55) and HcF9 (EC50 = 125.5 ± 10.65) and compounds 1 (EC50 = 16.06 ± 2.15) and 2 (EC50 = 25.37 ± 3.47) of Haematoxylum campechianum present significant relaxing activity as compared to papaverine (EC50 = 20.08 ± 2.0) as a positive control.

SUBMITTER: Escobar-Ramos A 

PROVIDER: S-EPMC6151460 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity.

Escobar-Ramos Armando A   Lobato-García Carlos Ernesto CE   Zamilpa Alejandro A   Gómez-Rivera Abraham A   Tortoriello Jaime J   González-Cortazar Manasés M  

Molecules (Basel, Switzerland) 20170824 9

<i>Haematoxylum campechianum</i> is a medicinal plant employed as an astringent to purify the blood and to treat stomach problems such as diarrhea and dysentery. A bio-guided chemical fractionation of the methanolic extract obtained from this plant allowed for the isolation of five compounds: two chalcones known as sappanchalcone (<b>1</b>); 3-deoxysappanchalcone (<b>2</b>); three homoisoflavonoids known as hematoxylol A (<b>3</b>); 4-<i>O</i>-methylhematoxylol (<b>4</b>); and, hematoxin (<b>5</  ...[more]

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