Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC6151509 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20170928 10
In an attempt to explore a new class of epidermal growth factor receptor (EGFR) inhibitors, novel 4-stilbenylamino quinazoline derivatives were synthesized through a Dimorth rearrangement reaction and characterized via IR, ¹H-NMR, <sup>13</sup>C-NMR, and HRMS. Methoxyl, methyl, halogen, and trifluoromethyl groups on stilbeneamino were detected. These synthesized compounds were evaluated for antitumor activity in vitro against eight human tumor cell lines with an MTS assay. Most synthesized compo ...[more]