Ontology highlight
ABSTRACT:
SUBMITTER: Dantas ED
PROVIDER: S-EPMC6151607 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Dantas Elen Diana ED de Souza Fabia Julliana Jorge FJJ Nogueira William Nascimento Litaiff WNL Silva Cláudia Cândida CC de Azevedo Pedro Henrique Antunes PHA Soares Aragão Cícero Flávio CF Almeida Patricia Danielle Oliveira de PDO Cardoso Mariana Filomena do Carmo MFDC da Silva Fernando de Carvalho FC de Azevedo Eduardo Pereira EP Guimarães Barbosa Euzébio E Lima Emerson Silva ES Ferreira Vitor Francisco VF Lima Ádley Antonini Neves de ÁAN
Molecules (Basel, Switzerland) 20170930 10
Chagas disease is an endemic parasitic infection that occurs in 21 Latin American countries. New therapies for this disease are urgently needed, as the only two drugs available (nifurtimox and benznidazol) have high toxicity and variable efficacy in the disease's chronic phase. Recently, a new chemical entity (NCE) named Pyranaphthoquinone (IVS320) was synthesized from lawsone. We report herein, a detailed study of the physicochemical properties and in vitro trypanocidal activity of IVS320. A se ...[more]