Ontology highlight
ABSTRACT:
SUBMITTER: Fu R
PROVIDER: S-EPMC6151647 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Fu Renzhong R Yang Yang Y Ma Xudong X Sun Yu Y Li Jin J Gao Hang H Hu Huaxing H Zeng Xiaojun X Yi Jun J
Molecules (Basel, Switzerland) 20170911 9
Efficient, eco-friendly and sustainable access to 3,4-dihydropyrimidin-2(1<i>H</i>)-ones directly from alcohols under microwave and solvent-free conditions has been reported. The practical protocol involves heteropolyanion-based catalyzed oxidation of alcohols to aldehydes with NaNO₃ as the oxidant followed by cyclocondensation with dicarbonyl compounds and urea or thiourea in a two-step, one-pot manner. Compatibility with different functional groups, good to excellent yields and reusable cataly ...[more]