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Current Development Status of MEK Inhibitors.

ABSTRACT: The current development status of mitogen-activated protein kinase kinase (MEK) inhibitors, including the preclinical data and clinical study progress, has been summarized in this review. Different MEK inhibitors, possessing specific physicochemical properties and bioactivity characteristics, may provide different options for patients seeking treatment for cancer. Moreover, the combination of the MEK inhibitors with other therapies-such as chemotherapy, targeted therapy, and immunotherapy-may be a promising approach for clinical use.

SUBMITTER: Cheng Y

PROVIDER: S-EPMC6151813 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Current Development Status of MEK Inhibitors.

Cheng Ying Y Tian Hongqi H

Molecules (Basel, Switzerland) 20170926 10

The current development status of mitogen-activated protein kinase kinase (MEK) inhibitors, including the preclinical data and clinical study progress, has been summarized in this review. Different MEK inhibitors, possessing specific physicochemical properties and bioactivity characteristics, may provide different options for patients seeking treatment for cancer. Moreover, the combination of the MEK inhibitors with other therapies-such as chemotherapy, targeted therapy, and immunotherapy-may be ...[more]

PMID: 28954413

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