Ontology highlight
ABSTRACT:
SUBMITTER: Morin P
PROVIDER: S-EPMC6152019 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Morin Pier P St-Coeur Patrick-Denis PD Doiron Jérémie A JA Cormier Marc M Poitras Julie J JJ Surette Marc E ME Touaibia Mohamed M
Molecules (Basel, Switzerland) 20170706 7
Glioblastoma multiforme (GBM) is an aggressive brain tumor that correlates with short patient survival and for which therapeutic options are limited. Polyphenolic compounds, including caffeic acid phenethyl ester (CAPE, <b>1a</b>), have been investigated for their anticancer properties in several types of cancer. To further explore these properties in brain cancer cells, a series of caffeic and ferulic acid esters bearing additional oxygens moieties (OH or OCH₃) were designed and synthesized. (C ...[more]