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Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine.

ABSTRACT: Three complexes, namely [Co(dmtp)?(OH?)?][CoCl?] (1), [Co(dmtp)?Cl?] (2) and [Co(dmtp)?(OH?)?]Cl??2H?O (3) (dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine), were synthesized and characterized by spectral (IR, UV-Vis-NIR), and magnetic measurements at room temperature, as well as single crystal X-ray diffraction. Complex (1) crystallizes in monoclinic system (space group C2/c), complex (2) adopts an orthorhombic system (space group Pbca), and complex (3) crystallizes in triclinic system (space group P1). Various types of extended hydrogen bonds and ?-? interactions provide a supramolecular architecture for all complexes. All species were evaluated for antimicrobial activity towards planktonic and biofilm-embedded microbial cells and influence on HEp-2 cell viability, cellular cycle and gene expression.

SUBMITTER: Marutescu L 

PROVIDER: S-EPMC6152184 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine.

Măruţescu Luminiţa L   Calu Larisa L   Chifiriuc Mariana Carmen MC   Bleotu Coralia C   Daniliuc Constantin-Gabriel CG   Fălcescu Denisa D   Kamerzan Crina Maria CM   Badea Mihaela M   Olar Rodica R  

Molecules (Basel, Switzerland) 20170722 7

Three complexes, namely [Co(dmtp)₂(OH₂)₄][CoCl₄] (<b>1</b>), [Co(dmtp)₂Cl₂] (<b>2</b>) and [Co(dmtp)₂(OH₂)₄]Cl₂∙2H₂O (<b>3</b>) (dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-<i>a</i>]pyrimidine), were synthesized and characterized by spectral (IR, UV-Vis-NIR), and magnetic measurements at room temperature, as well as single crystal X-ray diffraction. Complex (<b>1</b>) crystallizes in monoclinic system (space group <i>C</i>2/c), complex (<b>2</b>) adopts an orthorhombic system (space group <i>P</i>bca)  ...[more]

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