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Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera.

ABSTRACT: Five new phenolic compounds rynchopeterines A-E (1-5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A-E (1-4) exhibited significant antioxidant activities with IC₅₀ values of 7.67-12.3 ?g/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549.

SUBMITTER: Xiao H

PROVIDER: S-EPMC6152337 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera.

Xiao Huai H Yin Tian-Peng TP Dong Jian-Wei JW Wu Xiu-Mei XM Luo Qing Q Luo Jian-Rong JR Cai Le L Ding Zhong-Tao ZT

Molecules (Basel, Switzerland) 20170804 8

Five new phenolic compounds rynchopeterines A-E (1-5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A-E (1-4) exhibited significant antioxidant act ...[more]

PMID: 28777311

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