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New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production.

ABSTRACT: Three new benzenoid derivatives, lawsoinermone (1), inermidioic acid (2), and inermic acid (3) have been isolated from the aerial part of Lawsonia inermis, together with 11 known compounds (4-14). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4-6, 13 and 14 were evaluated for inhibition of nitric oxide production in LPS-stimulated product of nitrite in RAW 264.7 cells with IC50 values of 6.12, 16.43, 18.98, 9.30, 9.30 and 14.90 ?g/mL, respectively.

SUBMITTER: Yang CS

PROVIDER: S-EPMC6152715 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production.

Yang Chang-Syun CS Chen Jih-Jung JJ Huang Hui-Chi HC Huang Guan-Jhong GJ Wang Sheng-Yang SY Sung Ping-Jyun PJ Cheng Ming-Jen MJ Wu Ming-Der MD Kuo Yueh-Hsiung YH

Molecules (Basel, Switzerland) 20170605 6

Three new benzenoid derivatives, lawsoinermone (1), inermidioic acid (2), and inermic acid (3) have been isolated from the aerial part of Lawsonia inermis, together with 11 known compounds (4-14). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4-6, 13 and 14 were evaluated for inhibition of nitric oxide production in LPS-stimulated product of nitrite in RAW 264. ...[more]

PMID: 28587259

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New Diphenol and Isocoumarins from the Aerial Part of Lawsonia inermis and Their Inhibitory Activities against NO Production.

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