Unknown

Dataset Information

0

Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis.

ABSTRACT: Five new compounds including the glycosylated ?-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (3-5) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis.

SUBMITTER: Helaly SE 

PROVIDER: S-EPMC6152716 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis.

Helaly Soleiman E SE   Kuephadungphan Wilawan W   Phongpaichit Souwalak S   Luangsa-Ard Janet Jennifer JJ   Rukachaisirikul Vatcharin V   Stadler Marc M  

Molecules (Basel, Switzerland) 20170614 6

Five new compounds including the glycosylated β-naphthol (<b>1</b>, akanthol), a glycosylated pyrazine (<b>2</b>, akanthozine), and three amide derivatives including a hydroxamic acid derivative (<b>3</b>-<b>5</b>) were isolated from the spider-associated fungus <i>Akanthomyces novoguineensis</i> (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nem  ...[more]

Similar Datasets

Unknown Five new secondary metabolites produced by a marine-associated fungus, Daldinia eschscholzii.
| S-EPMC4245545 | biostudies-literature
Unknown Five new secondary metabolites from an endophytic fungus <i>Phomopsis</i> sp. SZSJ-7B.
| S-EPMC9702824 | biostudies-literature
Unknown Secondary metabolites from the fungus Emericella nidulans.
| S-EPMC4111234 | biostudies-literature
Unknown Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri.
| S-EPMC4728515 | biostudies-literature
Unknown Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora.
| S-EPMC6872701 | biostudies-literature
Unknown Secondary Metabolites from the Endophytic Fungus Xylaria sp. hg1009.
| S-EPMC5913051 | biostudies-literature
Unknown Asterogynins: secondary metabolites from a Costa Rican endophytic fungus.
| S-EPMC2951720 | biostudies-literature
Unknown Complete mitogenome of the entomopathogenic fungus <i>Akanthomyces lecanii</i>.
| S-EPMC7748497 | biostudies-literature
Unknown Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica.
| S-EPMC6274285 | biostudies-literature
Unknown Secondary Metabolites from the Root Rot Biocontrol Fungus Phlebiopsis gigantea.
| S-EPMC6100525 | biostudies-literature