Ontology highlight
ABSTRACT:
SUBMITTER: Spilovska K
PROVIDER: S-EPMC6152717 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20170616 6
A novel series of 6-chlorotacrine-scutellarin hybrids was designed, synthesized and the biological activity as potential anti-Alzheimer's agents was assessed. Their inhibitory activity towards human acetylcholinesterase (<i>h</i>AChE) and human butyrylcholinesterase (<i>h</i>BChE), antioxidant activity, ability to cross the blood-brain barrier (BBB) and hepatotoxic profile were evaluated in vitro. Among these compounds, hybrid <b>K1383</b>, bearing two methylene tether between two basic scaffold ...[more]