Ontology highlight
ABSTRACT:
SUBMITTER: Pan J
PROVIDER: S-EPMC6152908 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Pan Joshua J Meyers Robin M RM Michel Brittany C BC Mashtalir Nazar N Sizemore Ann E AE Wells Jonathan N JN Cassel Seth H SH Vazquez Francisca F Weir Barbara A BA Hahn William C WC Marsh Joseph A JA Tsherniak Aviad A Kadoch Cigall C
Cell systems 20180516 5
Protein complexes are assemblies of subunits that have co-evolved to execute one or many coordinated functions in the cellular environment. Functional annotation of mammalian protein complexes is critical to understanding biological processes, as well as disease mechanisms. Here, we used genetic co-essentiality derived from genome-scale RNAi- and CRISPR-Cas9-based fitness screens performed across hundreds of human cancer cell lines to assign measures of functional similarity. From these measures ...[more]