Ontology highlight
ABSTRACT:
SUBMITTER: Yang JS
PROVIDER: S-EPMC6152935 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature 20180912 7722
Starvation poses a fundamental challenge to cell survival. Whereas the role of autophagy in promoting energy homeostasis in this setting has been extensively characterized<sup>1</sup>, other mechanisms are less well understood. Here we reveal that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibits coat protein I (COPI) transport by targeting a GTPase-activating protein (GAP) towards ADP-ribosylation factor 1 (ARF1) to suppress COPI vesicle fission. GAPDH inhibits multiple other transport ...[more]