Dataset Information
Pharmacokinetics of ferric pyrophosphate citrate administered via dialysate and intravenously to pediatric patients on chronic hemodialysis.
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ABSTRACT:
SUBMITTER: Pratt RD
PROVIDER: S-EPMC6153505 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Pharmacokinetics of ferric pyrophosphate citrate administered via dialysate and intravenously to pediatric patients on chronic hemodialysis.
Pediatric nephrology (Berlin, Germany) 20180712 11
<h4>Background</h4>Iron deficiency is a common cause of anemia in pediatric patients with hemodialysis-dependent chronic kidney disease (CKD-5HD). Ferric pyrophosphate citrate (FPC, Triferic®) donates iron directly to transferrin, bypassing the reticuloendothelial system and avoiding iron sequestration. Administration of FPC via dialysate or intravenously (IV) may provide a suitable therapeutic option to current IV iron preparations for these patients.<h4>Methods</h4>The pharmacokinetics and saf ...[more]