Ontology highlight
ABSTRACT:
SUBMITTER: Nagatake T
PROVIDER: S-EPMC6153728 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nagatake Takahiro T Suzuki Hidehiko H Hirata So-Ichiro SI Matsumoto Naomi N Wada Yasuko Y Morimoto Sakiko S Nasu Ayaka A Shimojou Michiko M Kawano Mitsuo M Ogami Kentaro K Tsujimura Yusuke Y Kuroda Etsushi E Iijima Norifumi N Hosomi Koji K Ishii Ken J KJ Nosaka Tetsuya T Yasutomi Yasuhiro Y Kunisawa Jun J
International immunology 20180901 10
We previously reported that Ag85B-expressing human parainfluenza type 2 virus (Ag85B-rHPIV2) was effective as a nasal vaccine against tuberculosis in mice; however, the mechanism by which it induces an immune response remains to be investigated. In the present study, we found that organogenesis of inducible bronchus-associated lymphoid tissue (iBALT) played a role in the induction of antigen-specific T cells and IgA antibody responses in the lung of mice intra-nasally administered Ag85B-rHPIV2. ...[more]