Ontology highlight
ABSTRACT:
SUBMITTER: Kudriaeva A
PROVIDER: S-EPMC6153759 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kudriaeva Anna A Galatenko Vladimir V VV Maltseva Diana V DV Khaustova Nadezhda A NA Kuzina Ekaterina E Tonevitsky Alexander G AG Gabibov Alexander A Belogurov Alexey A
Molecules (Basel, Switzerland) 20170515 5
Astrocytes are considered to be an important contributor to central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released by lymphocytes, penetrating the blood-brain barrier-in particular, the classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here the transcriptomal profiling of astrocytes treated using IFNγ and benztropine, a putative remyelinization agent. Our findings indicate that the e ...[more]