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Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic.


ABSTRACT: Plasmodium falciparum artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch (PfK13) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre (n = 14), Amapá (n = 15), Amazonas (n = 30), and Pará (n = 10). After DNA alignment with the 3D7 reference sequence, all samples were found to be wild type. These data provide a baseline for PfK13 and reinforce the pertinence of artemisinin combination therapy in Brazilian areas.

SUBMITTER: Gomes LR 

PROVIDER: S-EPMC6153804 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic.

Gomes Larissa Rodrigues LR   Lavigne Aline A   Peterka Cassio Leonel CL   Brasil Patrícia P   Ménard Didier D   Daniel-Ribeiro Cláudio Tadeu CT   Ferreira-da-Cruz Maria de Fátima MF  

Antimicrobial agents and chemotherapy 20180924 10


<i>Plasmodium falciparum</i> artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch (<i>PfK13</i>) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre (<i>n</i> = 14), Amapá (<i>n</i> = 15), Amazonas (<i>n</i> = 30), and Pará (<i>n</i> = 10). After DNA alignment with the 3D7 reference sequence, all samples were found to be wild type. These data pro  ...[more]

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