Unknown

Dataset Information

0

First Clinical Isolation of an Azole-Resistant Aspergillus fumigatus Isolate Harboring a TR46 Y121F T289A Mutation in South America.

ABSTRACT: One of the most recently described Aspergillus fumigatusCYP51A-mediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.

SUBMITTER: Isla G 

PROVIDER: S-EPMC6153829 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

First Clinical Isolation of an Azole-Resistant Aspergillus fumigatus Isolate Harboring a TR46 Y121F T289A Mutation in South America.

Isla Guillermina G   Leonardelli Florencia F   Tiraboschi Iris N IN   Refojo Nicolás N   Hevia Alejandra A   Vivot Walter W   Szusz Wanda W   Córdoba Susana B SB   García-Effron Guillermo G  

Antimicrobial agents and chemotherapy 20180924 10

One of the most recently described <i>Aspergillus fumigatus</i><i>CYP51A</i>-mediated azole resistance mechanisms is TR46 Y121F T289A. Clinical <i>A. fumigatus</i> strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical <i>A. fumigatus</i> strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstratin  ...[more]

Similar Datasets

Unknown Azole-resistant Aspergillus fumigatus harboring TR<sub>34</sub>/L98H, TR<sub>46</sub>/Y121F/T289A and TR<sub>53</sub> mutations related to flower fields in Colombia.
| S-EPMC5372364 | biostudies-literature
Unknown First detection of TR46/Y121F/T289A and TR34/L98H alterations in Aspergillus fumigatus isolates from azole-naive patients in Denmark despite negative findings in the environment.
| S-EPMC4135837 | biostudies-literature
Unknown First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States.
| S-EPMC4702720 | biostudies-literature
Unknown Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/L98H azole resistance mechanism.
| S-EPMC3421523 | biostudies-literature
Unknown Azole-resistant Aspergillus fumigatus, Iran.
| S-EPMC3647519 | biostudies-literature
Unknown Quantitative Analysis of Single-Nucleotide Polymorphism for Rapid Detection of TR34/L98H- and TR46/Y121F/T289A-Positive Aspergillus fumigatus Isolates Obtained from Patients in Iran from 2010 to 2014.
| S-EPMC4704245 | biostudies-literature
Unknown Fitness Studies of Azole-Resistant Strains of Aspergillus fumigatus.
| S-EPMC4649223 | biostudies-literature
Unknown Azole preexposure affects the Aspergillus fumigatus population in patients.
| S-EPMC3421863 | biostudies-literature
Unknown Azole drug import into the pathogenic fungus Aspergillus fumigatus.
| S-EPMC4432157 | biostudies-literature
Unknown Environmental isolates of azole-resistant Aspergillus fumigatus in Germany.
| S-EPMC4468681 | biostudies-literature