In Vitro Antiviral Activity of Cabotegravir against HIV-2.
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ABSTRACT:
SUBMITTER: Smith RA
PROVIDER: S-EPMC6153831 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
<i>In Vitro</i> Antiviral Activity of Cabotegravir against HIV-2.
Smith Robert A RA Wu Vincent H VH Zavala Christopher G CG Raugi Dana N DN Ba Selly S Seydi Moussa M Gottlieb Geoffrey S GS
Antimicrobial agents and chemotherapy 20180924 10
We examined the antiviral activity of the integrase inhibitor (INI) cabotegravir against HIV-2 isolates from INI-naive individuals. HIV-2 was sensitive to cabotegravir in single-cycle and spreading-infection assays, with 50% effective concentrations (EC<sub>50</sub>s) in the low to subnanomolar range; comparable results were obtained for HIV-1 in both assay formats. Our findings suggest that cabotegravir should be evaluated in clinical trials as a potential option for antiretroviral therapy and ...[more]
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