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In Vitro Antiviral Activity of Cabotegravir against HIV-2.


ABSTRACT: We examined the antiviral activity of the integrase inhibitor (INI) cabotegravir against HIV-2 isolates from INI-naive individuals. HIV-2 was sensitive to cabotegravir in single-cycle and spreading-infection assays, with 50% effective concentrations (EC50s) in the low to subnanomolar range; comparable results were obtained for HIV-1 in both assay formats. Our findings suggest that cabotegravir should be evaluated in clinical trials as a potential option for antiretroviral therapy and preexposure prophylaxis in HIV-2-prevalent settings.

SUBMITTER: Smith RA 

PROVIDER: S-EPMC6153831 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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<i>In Vitro</i> Antiviral Activity of Cabotegravir against HIV-2.

Smith Robert A RA   Wu Vincent H VH   Zavala Christopher G CG   Raugi Dana N DN   Ba Selly S   Seydi Moussa M   Gottlieb Geoffrey S GS  

Antimicrobial agents and chemotherapy 20180924 10


We examined the antiviral activity of the integrase inhibitor (INI) cabotegravir against HIV-2 isolates from INI-naive individuals. HIV-2 was sensitive to cabotegravir in single-cycle and spreading-infection assays, with 50% effective concentrations (EC<sub>50</sub>s) in the low to subnanomolar range; comparable results were obtained for HIV-1 in both assay formats. Our findings suggest that cabotegravir should be evaluated in clinical trials as a potential option for antiretroviral therapy and  ...[more]

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