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Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity.

ABSTRACT: A new triflavanoid, kandelin B-5 (1), was isolated from the rhizomes of Smilax china L., together with six known phenylpropanoid substituted flavan-3-ols (2-7), nine flavonoids (8-16), two stilbenoids (17, 18), and two other compounds (19, 20). The structure of compound 1 was determined on the basis of 1D, 2D NMR and HR-ESI-MS data, as well as chemical method. Compounds 2-5, 8-12, 15, 17, and 19 were evaluated for anti-inflammatory activity. Only compounds 10, 15 and 17 showed slightly IL-1? expression inhibitory activities on LPS induced THP-1 cells, with inhibition rate of 15.8%, 37.3%, and 35.8%, respectively, at concentration of 50 ?g/mL.

SUBMITTER: Zhong C

PROVIDER: S-EPMC6154459 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity.

Zhong Cheng C Hu Deng D Hou Lian-Bing LB Song Lu-Yao LY Zhang Ying-Jun YJ Xie Yang Y Tian Li-Wen LW

Molecules (Basel, Switzerland) 20170403 4

A new triflavanoid, kandelin B-5 (1), was isolated from the rhizomes of Smilax china L., together with six known phenylpropanoid substituted flavan-3-ols (2-7), nine flavonoids (8-16), two stilbenoids (17, 18), and two other compounds (19, 20). The structure of compound 1 was determined on the basis of 1D, 2D NMR and HR-ESI-MS data, as well as chemical method. Compounds 2-5, 8-12, 15, ...[more]

PMID: 28368360

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