Ontology highlight
ABSTRACT:
SUBMITTER: Lin B
PROVIDER: S-EPMC6154684 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20170417 4
Described herein is the development of a facile and efficient methodology for the synthesis of novel turmerone motif-fused 3,3'-pyrrolidinyl-dispirooxindoles 3-5 via a multicomponent 1,3-dipolar cycloaddition of dienones <b>2</b> with azomethine ylides (thermally generated in situfrom isatins and proline or thioproline or sarcosine). Products bearing four or three consecutive stereocenters consist of two oxindole moieties and a pyrrolidinyl core, including vicinal spiroquaternary stereocenters f ...[more]