Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy.

ABSTRACT: The administration of neoadjuvant chemotherapy (NAC) preceding radical cystectomy benefits overall survival for patients with muscle-invasive bladder cancer (MIBC). However, the relationship between the genetic profiling of MIBC and NAC response remains unclear. Here, a mutation panel of six cancer-associated genes (TSC1, FGFR3, TERT, TP53, PIK3CA and ERBB2) and an immunohistochemistry (IHC) panel containing eight bladder cancer (BC) biomarkers (EGFR, RRM1, PD-L1, BRCA1, TUBB3, ERCC, ERCC1, aberrantly glycosylated integrin ?3?1 (AG) and CK5/6) were developed. BC samples from patients who showed a pathologic response (n?=?39) and non-response (n?=?13) were applied to the panel analysis. ERBB2, FGFR3 and PIK3CA exclusively altered in the responders group (19/39, 48.7%), in which FGFR3 mutations were significantly enriched in patients with a response in the cohort (14/39, 35.9%; P?=?0.01). Additionally, strong expression of ERCC1 was associated with a pathologic response (P?=?0.01). However, positive lymph node metastasis (P?

SUBMITTER: Yang Z 

PROVIDER: S-EPMC6154770 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature