Ontology highlight
ABSTRACT:
SUBMITTER: Ferguson A
PROVIDER: S-EPMC6154782 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Ferguson Amy A Lyall Laura M LM Ward Joey J Strawbridge Rona J RJ Cullen Breda B Graham Nicholas N Niedzwiedz Claire L CL Johnston Keira J A KJA MacKay Daniel D Biello Stephany M SM Pell Jill P JP Cavanagh Jonathan J McIntosh Andrew M AM Doherty Aiden A Bailey Mark E S MES Lyall Donald M DM Wyse Cathy A CA Smith Daniel J DJ
EBioMedicine 20180814
<h4>Background</h4>Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder.<h4>Methods</h4>We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were use ...[more]