Dataset Information

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is recognized as a liver manifestation of metabolic syndrome, accompanied with excessive fat accumulation in the liver and other vital organs. Ectopic fat accumulation was previously associated with negative effects at the systemic and local level in the human body. Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non-diabetic men with NAFLD, using the inflammation-associated proteome, lipidome and metabolome. Myocardial and hepatic triglycerides were measured with magnetic spectroscopy while function of left ventricle, pericardial and epicardial fat, subcutaneous and visceral adipose tissue were measured with magnetic resonance imaging. Measured ectopic fat depots were profiled and predicted using a Random Forest algorithm, and by estimating the Area Under the Receiver Operating Characteristic curves. We have identified distinct metabolic signatures of fat depots in the liver (TAG50:1, glutamate, diSM18:0 and CE20:3), pericardium (N-palmitoyl-sphinganine, HGF, diSM18:0, glutamate, and TNFSF14), epicardium (sphingomyelin, CE20:3, PC38:3 and TNFSF14), and myocardium (CE20:3, LAPTGF-?1, glutamate and glucose). Our analyses highlighted non-invasive biomarkers that accurately predict ectopic fat depots, and reflect their distinct metabolic signatures in subjects with NAFLD.

SUBMITTER: Lovric A

PROVIDER: S-EPMC6155005 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.

Lovric Alen A Granér Marit M Bjornson Elias E Arif Muhammad M Benfeitas Rui R Nyman Kristofer K Ståhlman Marcus M Pentikäinen Markku O MO Lundbom Jesper J Hakkarainen Antti A Sirén Reijo R Nieminen Markku S MS Lundbom Nina N Lauerma Kirsi K Taskinen Marja-Riitta MR Mardinoglu Adil A Boren Jan J

Scientific reports 20180921 1

Non-alcoholic fatty liver disease (NAFLD) is recognized as a liver manifestation of metabolic syndrome, accompanied with excessive fat accumulation in the liver and other vital organs. Ectopic fat accumulation was previously associated with negative effects at the systemic and local level in the human body. Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non-diabetic men with NAFLD, using the inflammation-associate ...[more]

PMID: 30242179

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Dataset Information

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.

Publications

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.

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