Ontology highlight
ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC6155060 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Guo Yuxuan Y Jardin Blake D BD Zhou Pingzhu P Sethi Isha I Akerberg Brynn N BN Toepfer Christopher N CN Ai Yulan Y Li Yifei Y Ma Qing Q Guatimosim Silvia S Hu Yongwu Y Varuzhanyan Grigor G VanDusen Nathan J NJ Zhang Donghui D Chan David C DC Yuan Guo-Cheng GC Seidman Christine E CE Seidman Jonathan G JG Pu William T WT
Nature communications 20180921 1
After birth, cardiomyocytes (CM) acquire numerous adaptations in order to efficiently pump blood throughout an animal's lifespan. How this maturation process is regulated and coordinated is poorly understood. Here, we perform a CRISPR/Cas9 screen in mice and identify serum response factor (SRF) as a key regulator of CM maturation. Mosaic SRF depletion in neonatal CMs disrupts many aspects of their maturation, including sarcomere expansion, mitochondrial biogenesis, transverse-tubule formation, a ...[more]