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Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators.

ABSTRACT: A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, ¹H-NMR and mass spectroscopy. The final compounds have been screened for in vitro pro-inflammatory cytokine inhibitory and in vivo anti-inflammatory activity. The biological results revealed that among all tested compounds some fused pyrroles, namely the pyrrolopyridines 3i and 3l, show promising activity. A docking study of the active synthesized molecules confirmed the biological results and revealed a new binding pose in the COX-2 binding site.

SUBMITTER: Said Fatahala S

PROVIDER: S-EPMC6155178 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators.

Said Fatahala Samar S Hasabelnaby Sherifa S Goudah Ayman A Mahmoud Ghada I GI Helmy Abd-El Hameed Rania R

Molecules (Basel, Switzerland) 20170317 3

A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, ¹H-NMR and mass spectroscopy. The final compounds have been screened for in vitro pro-inflammatory cytokine inhibitory and in vivo anti-inflammatory activity. The biological results revealed that among all tested compounds some fused pyrroles, namely the pyrrolopyridines 3i and 3l, show promising activity. A docking ...[more]

PMID: 28304349

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